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Gainesville is the county seat of Alachua County, Florida, and the most populous city in North Central Florida, with a population of 145,212 in 2022. It is the principal city of the Gainesville metropolitan area with a population of 350,903 in 2022. Gainesville is home to the University of Florida, the fourth-largest public university campus by enrollment in the United States as of the 2021–2022 academic year. The university is represented by the Florida Gators sports teams in NCAA competitions. == History == There is archeological evidence, from about 12,000 years ago, of the presence of Paleo-Indians in the Gainesville area, although it is not known if there were any permanent settlements.